Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin.

Further analysis of the differentially methylated probes in all primary human keratinocytes from 13 different donors also showed a moderate, but robust and highly significant ( p = 1.4 × 10 −33 , t -test) reduction of DNA methylation in the DHM-treated cells ( Figure 2B ).

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Correlating the donor age to the predicted biological age of the cell populations revealed a clear trend, which justifies applying the ex vivo developed age clocks to cell culture samples, particularly to identify relative changes after treatment ( Supplementary Figure S6 ).

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