Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions.

There was a small, apparent progressive drop in the number of PDX1 + /SOX9 + as well as the number of PDX1 + /SOX9 + /NKX6-1 + cells that did not reach statistical significance ( Figure 2H–K , Figure 2—figure supplement 1K–N ).

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