Probing Peptidylprolyl Bond cis/trans Status Using Distal ¹⁹ F NMR Reporters.

Indeed, there was a clear trend for electron‐rich aromatics to promote higher cis ‐Pro in the order: Trp‐Pro>Tyr‐Pro>Phe‐Pro>His‐Pro.[ 9 , 13 , 36 ] It was also clear that polar side chains, for example, Ser (12 %), Thr (13 %) Asp (13.5 %) promote a slightly higher cis ‐Pro population in X‐Pro systems compared with Ala‐Pro (10.5 %), while Arg (8 %) or Lys (9 %) in this position leads to a subtle decrease in the cis ‐Pro population.

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