Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis.

Resting energy expenditure measured after 12 weeks of high fat feeding, prior to emergence of a body weight difference between the genotypes, trended lower in PexRAP-AKO mice, but the effects did not reach statistical significance ( Figure S1G–H ), possibly because indirect calorimetry is not sufficiently sensitive to detect subtle changes in energy expenditure that impact body weight over a prolonged period [ 21 , 22 ].

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