Comprehensive blood metabolomics profiling of Parkinson's disease reveals coordinated alterations in xanthine metabolism.

p value = 1.34E-04) and a nominally significant decrease in de novo PD vs. control ( p value = 9.41E-04; adj. p value = 5.86E-02), is a furan fatty acid previously suggested as a marker for fish oil intake 28 , which could indicate a diet with high levels of omega-3 fatty acids.

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While these changes are highly significant in de novo patients, they are not observed when comparing only treated PD patients vs. controls after multiple hypothesis testing adjustments (see Supplementary Table 7 ).

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