Gene Expression and Autoantibody Analysis Revealing Distinct Ancestry-Specific Profiles Associated With Response to Rituximab in Refractory Systemic Lupus Erythematosus.

Arthritis Rheumatol · 2023 · PMC10953047 · PMID 36409591

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Although the cluster with low IFN score (NEA‐1) was adversely associated with treatment response among SLE patients of non‐European ancestry, SLE patients of European ancestry in the cluster with low IFN score (EA‐3) had the lowest serologic and clinical disease activity and in fact showed a trend toward a more favorable response.

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