Inhibition of <i>CERS1</i> in skeletal muscle exacerbates age-related muscle dysfunction.

Cers1 knockdown in differentiating mouse muscle cells showed only a weak trend to reduce mTORC1 and its downstream targets (new Fig S4A).

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Furthermore, ablation of Cers1 in aged muscle showed a trend towards increased fibrosis ( Figure 3F ) and more centralized nuclei ( Figure 3G ).

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