FOSL1 showed a trend towards a positive correlation with AP4 in 471 primary CRC samples of The Cancer Genome Atlas Colon Adenocarcinoma (TCGA‐COAD) cohort and in an independent patient cohort ( GSE13294 ) (Supplementary Figure S2D ).
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AP4 induces JNK1 and a miR-22-3p/FOSL1 feed-forward loop to activate AP-1 and promote colorectal cancer metastasis.
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