However, our study showed no efficacy of trofinetide on MBA, and this can be attributed to the small sample size due to a low number of included studies that failed to reach statistical significance.
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Safety and efficacy of trofinetide in Rett syndrome: a systematic review and meta-analysis of randomized controlled trials.
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The sentences
However, using lower doses did not lead to a highly significant OR regarding the risk of all side effects, including diarrhea and vomiting.