B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1.

This demonstrated a highly significant association of the gene-proximal BAP1 binding sites with the genes involved in proteosome-dependent protein degradation, DNA damage response, and protein trafficking, and the association of the gene-distal BAP1 binding sites with the genes involved in the regulation of transcription and RNA processing ( Figure 5B , Supplementary Tables S3B, C ).

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While Bap1 fl/fl mb1- Cre B cells showed a trend toward impaired cell proliferation relative to the control B cells ( Figures 4G, I, J ), there were no differences in class switching per cell division between the Bap1 -genotypes ( Figure 4K ), consistent with our findings with the Bap1 fl/fl Cγ1- Cre B cells ( Figure 4F , Supplementary Figure S6B ).

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