Impact of Hyperuricemia and Urate-Lowering Agents on Cardiovascular Diseases.

Clin Med Insights Cardiol · 2024 · PMC10962038 · PMID 38529322

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

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boldest claim

The sentences

did not reach statistical significanceP = 0.090so close (0.05 < p ≤ 0.1)

The average serum level of uric acid was 5.81 ± 1.81 mg/dl, The study found a positive correlation between the measured UA level and the calculated HEART score, but the correlation did not reach statistical significance ( R = 0.375, P = 0.090). 59 Cardiovascular Effect of Urate Lowering Agents International and European guidelines for managing hyperuricemia recommend allopurinol as the first-line drug, with febuxostat, another xanthine oxidase inhibitor, as the second-line option.

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highly significantno p-value reported

The study showed that subjects treated with urate-lowering therapy experienced a highly significant reduction in uric acid levels and blood pressure compared to those in the placebo group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.