showed a trendP = 0.108
In further exploring its relevance to the clinical diagnoses of dementia, Fisher’s exact tests revealed that clusters have a statistically significant association with the Braak staging of dementia ( P = 0.0025) and showed a trend of association with diagnoses of dementia by the NINCDS-ADRDA Alzheimer’s criteria ( P = 0.108), one of the most widely used criteria in the diagnosis of Alzheimer’s disease.