The risk of antidepressant-induced hyponatremia: A meta-analysis of antidepressant classes and compounds.

Eur Psychiatry · 2024 · PMC10966618 · PMID 38403888

Europe PMC DOI

hedged sentence

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

did not reach statistical significancep = 0.064so close (0.05 < p ≤ 0.1)

We observed a trend of an increased risk for SNRIs compared to SSRIs in geriatric populations, but this association did not reach statistical significance (any hypoNa: k = 5 studies, OR = 1.307 [0.985–1.734], p = 0.064, I 2 = 62.96; clinically relevant hypoNa: k = 4 studies, OR = 1.244 [0.997–1.552], p = 0.054, I 2 = 50.14; see Supplementary Figures S46 and S47 ).

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