CDKN2A-p16 Deletion and Activated KRAS<sup>G12D</sup> Drive Barrett's-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions.

Although mice with p16KO had higher dysplasia scores, this did not reach statistical significance ( P = .14; Figure 2 B ), and no significant differences in dysplasia were seen at 4, 9, or 15 months ( P = .49, P = .20, and P = .37, respectively).

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