SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome.

These results indicate that while only a small number of cytokines/chemokines were elevated in Dp16;ACE2 mice at the statistically significant level, a clear trend exists in which a large number of pro-inflammatory cytokines and chemokines were detected in the lungs at higher levels 4 days p.i. in Down syndrome mice. 3.5.

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