Peripheral Blood B-Cell Subsets Frequency and Distribution and the BSF-2(IL-6) to CSIF:TGIF(IL-10) Ratio as Severity-Associated Signatures in Primary Open-Angle Glaucoma: A Case-Controlled Study.

Upon testing the distribution of different B-cell subsets in POAG patients, there was a highly significant increase in the frequencies of the DN B-cell subset (CD19+CD27−IgD−) and the naïve B-cell subset (CD19+CD27−lgD+) ( p < 0.001) for all POAG patients, while a significant decrease in the unswitched memory B-cell subset (CD19+CD27+IgD+) ( p < 0.001) was found in this group as compared with the control group.

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Currently, the levels of CSIF:TGIF(IL-10) were negatively correlated with POAG MD of VF; however, this correlation did not reach statistical significance.

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