We identified a weak trend associating SNCA and GBA1 expressions with human serum albumin levels in depressive patients at inclusion (ρ = 0.164, p = 0.064, and ρ = 0.157, p = 0.079, respectively), which appeared stronger in the male subgroup (ρ = 0.315, p = 0.014; ρ = 0.230, p = 0.077), and particularly evident in medicated patients (ρ = 0.287, p = 0.019; ρ = 0.255, p = 0.042).
Associations of SNCA, GBA1, and UGCG Expressions with Depression Severity and Anxiety Based on the elevated gene expression levels observed in depressed patients compared to unaffected individuals, we conducted an exploratory analysis to determine whether high gene expression levels correlated with depression severity as assessed by clinicians (HAM-D, MADRS) or self-evaluation (BDI-II) with subsequent sex-stratified analysis in the event of nominally significant effects.