a negative trendp = 0.1
Correlation analyses in this subgroup of patients showed a negative correlation between TF volume and age as observed in the entire cohort (r P = – 0.3, p = 0.01, 95% CI [ – 0.5, – 0.09]) as well as a negative trend between TF volume and disease duration (r P = – 0.2, p = 0.1, 95% CI[ – 0.4, 0.1]) and Expanded Disability Status Scale (EDSS) (tau = – 0.2, p = 0.1) (Fig. 2 G). 135 patients with VCDs were also included in the analysis.