did not reach statistical significancep = 0.0749
Despite these immune-conferring events, the rise in anti-S/RBD titer did not reach statistical significance (2.1-fold increase, p = 0.0749; Wilcoxon test), and while the neutralizing activity revealed a statistically significant increase, the change was modest (median increase from 97.0% to 97.9%, p = 0.0015; Wilcoxon test).