The Effectiveness of the Third Dose of COVID-19 Vaccine: When Should It Be Performed?

Notably, the interaction effect between the time elapsed since completion of the vaccine cycle and the administration of the booster dose was highly significant when tested with the Wald statistic ( p < 0.001).

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Even though a previous infection might be associated to an increased protective effect of the booster dose, the differential effect of the booster dose in reinfected and not reinfected HCWs did not reach statistical significance.

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