Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes.

Likewise, it showed a trend towards higher proportions of CD8 + T and C-monocyte cells (Additional file 1 : Fig.

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Verapamil, a drug that improved mixed-meal-stimulated C-peptide area under the curve and reduced the insulin requirement in a phase II trial [ 79 ], also reduced the TMZ score based on monocyte DEGs and had a marginally significant effect on the overall TMZ score (Fig. 5 e; Additional file 1 : Fig.

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