Reducing Abdominal Aortic Aneurysm Progression by Blocking Neutrophil Extracellular Traps Depends on Thrombus Formation.

Here, a significant trend was detected regarding the primary location of NETs in the vessel wall at day 8 as opposed to the thrombus at day 28 (Fisher exact test, P = 0.048) ( Supplemental Figure 1 ).

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The downstream NET inhibitors ( Figure 5B ), which were not significant in the total AngII cohort, had a lower mean aortic volume increase at day 27 of 211% ± 12% compared with PBS controls (282% ± 27%) when specifically analyzing the thrombus subgroup, showing a statistical trend for growth reduction ( P = 0.081).

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