Additionally, we observed a slight increase in STAT3 protein phosphorylation in IL-4-stimulated macrophages, which was partially inhibited by 23-HBA at a concentration of 20 μM, but this effect did not reach statistical significance (Fig. 2 A).
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23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling.
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