Barely Significant
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Risk-reducing decisions regarding germline <i>BRCA</i> pathogenic variant: focusing on the timing of genetic testing and RRSO.

J Med Genet · 2024 · PMC10982634 · PMID 38124001

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showed a trendno p-value reported
Both showed a trend toward younger age g BRCA1 patients.

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an increasing trendno p-value reported
However, an increasing trend was observed for RRSO being performed on those with HBOC associated with a family history of first-degree and second-degree relatives or a family history of OC (p=0.035 and <0.001 respectively).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.