A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence.

Transposon expression (p < 0.0001) was elevated, and intron retention showed a trend toward elevation (p = 0.14), in the liver of 26-month-old mice, suggesting these age-related transcriptional defects might be conserved between species ( Figure 1—figure supplement 4A, B ; Figure 1—figure supplement 5 ).

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