a decreasing trendP = 1.00
For both PCV13 and PPV23 vaccines, the vaccine serotype coverage among the isolates showed a decreasing trend between 2017 - 2019 and 2020 - 2022 ( P = 1.00 for PCV13 and P = 0.12 for PPSV23), with a parallel increase in the non-vaccine types (NVTs) ( P = 0.08).