Immunogenicity and efficacy of VLA2001 vaccine against SARS-CoV-2 infection in male cynomolgus macaques.

All VLA2001 vaccinated animals raised serum IgGs against the homologous S protein as early as week 2 post first vaccine injection ( p = 0.0078 for each vaccinated group compared to controls, non-parametric Kruskal-Wallis and Dunn’s multiple comparisons tests; n = 8 per group) with slightly increased levels in Group High compared to Group Medium which did not reach statistical significance (Fig. 2b and Supplementary Fig. 1 ).

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