Astrocyte expression of aging-associated markers positively correlates with neurodegeneration in the frontal lobe of the rhesus macaque brain.

When looking at the intensity of FJC staining relative to DAPI staining, there was a general increase with age across all brain regions ( Figures 8E – H ), with a statistically significant positive correlation with age in the frontal ( Figure 8E ; p = 0.0030) and parietal ( Figure 8G ; p = 0.0481) lobes and a trend toward significance in the cerebellum ( Figure 8H ; p = 0.0720).

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This same pattern was observed in the cerebellum but did not reach statistical significance ( Figure 4J – L ).

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