Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.

When expressed together with dsRed or Ngn2 in control and patient pAstros (3 and 7 DPT, Figure 3 A), the PERK sensor showed a trend to higher expression in dsRed-transduced patient pAstros than controls at 3 DPT ( Figures 3 C and 3D), though this was also highly variable across lines.

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