However, a clear trend of interaction could not be identified, which might be due to effective concentrations of the antibiotics being much lower than their actual MIC values, i.e., RIF was tested at concentrations 5- and 20-fold lower than their actual MIC values, while this being 4- and 16-fold reduction for CLA tested at 1xMIC and 1/4xMIC values, respectively.
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Amoxicillin/clavulanate in combination with rifampicin/clarithromycin is bactericidal against Mycobacterium ulcerans.
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