Abrupt Decline in Estimated Glomerular Filtration Rate after Initiating Sodium-Glucose Cotransporter 2 Inhibitors Predicts Clinical Outcomes: A Systematic Review and Meta-Analysis.

Secondary outcomes: hospitalized heart failure and cardiovascular death There was a non-significant reduction in the hazard of the composite outcome of hospitalized heart failure and cardiovascular death in the dipping group, but the difference did not reach statistical significance (HR, 0.824; 95% CI, 0.633 to 1.074; I 2 =0%; sensitivity analysis, consistent results) ( Fig. 4 , Supplementary Fig. 4A ).

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