52 , 53 This phenomenon of humoral immunity divergence was also observed in the validation cohorts, where we found genes upregulated by patients with an NKG2A + bias in the chikungunya cohort to display significant overlap with antibody-associated genes and nearly significant overlap for the other COVID-19 cohort ( Figure 2 G).
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Integrative systems biology reveals NKG2A-biased immune responses correlate with protection in infectious disease, autoimmune disease, and cancer.
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