Comprehensive Sex-Stratified Genetic Analysis of 28 Blood Biomarkers and Depression Reveals a Significant Association between Depression and Low Levels of Total Protein in Females.

For the multiple regression analysis, only the most highly significant biomarker (based on univariate regression results) in these clusters was used, and less significant biomarkers in the cluster were omitted.

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Further fine-grained analysis, using a sliding 100 kb window across the locus, implemented for three nominally significant SNP-dense loci (number of SNPs >1,000) reported two regions with significant h 2 observed for both total protein and PND, located sequentially within the 5q13.3 locus and implicating IQ motif-containing GTPase activating protein 2 ( IQGAP2 ) ( Table 1 ; online suppl.

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