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Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independence.

Oncogene · 2024 · PMC10997519 · PMID 38388711

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Unidirectional CAF2 signaling through soluble factors was indeed able to decrease ERE activity in both MCF7 and T47D cell lines, yet in BT474 this did not reach statistical significance (Fig. 2G–I ).

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