Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers.

More amyloid pathology correlated with less tau pathophysiology, especially in carriers of APOE4 and BCHE-K Multiple regression analyses indicated that associations with amyloid pathology (inversely indexed by CSF Aβ 42 ) included APOE4 carrier status ( P < 0.029), larger total brain ventricle volume ( P < 0.021), less synaptic injury (Ng, P < 0.001), less tau (p-tau 181 , P = 0.005), and showed a trend for an association with less glial activation (YLK-40, P = 0.097).

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