Subretinal AAV delivery of RNAi-therapeutics targeting <i>VEGFA</i> reduces choroidal neovascularization in a large animal model.

However, the difference did not reach statistical significance (p = 0.195).

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33 Highly significant reporter knockdown was observed for the VMD2-intron-miR324-13-miR451-12 construct (knockdown efficacy of ∼55%) compared with the corresponding HIV-targeting irrelevant control (S1/S2) (p < 0.01) ( Figure 2 B).

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