A recent, triple-masked, randomized clinical trial showed that the incidence of new-onset adrenal insufficiency directly after surgery was 11% (95% CI 6.9–15.2%) in the non-hydrocortisone group compared to 6.4% (95% CI 3.2–9.7%) in the hydrocortisone group which did not reach statistical significance.
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Basal cortisol in relation to metyrapone confirmation in predicting adrenal insufficiency after pituitary surgery.
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