Evidence from 4 trials that were highly heterogenous showed a trend toward a positive effect of vitamin D supplementation on reducing the incidence of cold/influenza. 96 , 97 , 101 , 102 However, subgroup analysis of 3 of the trials to assess possible sources of heterogeneity demonstrated that supplementation with vitamin D at more than 1000 IU/d significantly reduced the incidence of cold/influenza. 96 , 101 , 102 One of the trials analyzed had some limitations. 102 It was not blinded to participants and trial assessors, leading to downgrading of the evidence.
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High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis.
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