Does Atrial Septal Anatomy Still Matter in the Etiological Evaluation of Ischemic Stroke Beyond the Age of 60?

An inverse association between the presence of a PFO and history of hypertension failed to reach statistical significance (42.3% versus 54.5%, P =0.07).

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30 In older patients, Mazzucco et al had observed an association between large PFO and cryptogenic stroke that did not quite reach statistical significance (adjusted OR, 1.94 [95% CI, 0.99–3.80]). 13 Of note, the imaging modality used in this study does not allow detection of ASA. 13 Handke et al observed an association between PFO‐ASA and cryptogenic stroke in older patients (OR, 3.88 [95% CI, 1.78–8.46]), but no quantification of shunt size

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