In a cohort of offspring born to mothers with post-traumatic stress disorder (PTSD) from war-related trauma, preliminary data looking at the DNA methylation in candidate genes, including cortisol pathway genes, showed higher cortisol levels and differences in DNA methylation, although they did not reach statistical significance [ 21 ].
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Placental Cortisol Dysregulation in Mothers with Experiences of Childhood Adversity: Potential Mechanisms and Clinical Implications.
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