In the case of each compound ( 19 – 22 ), a clear trend of increasing biological activity against time was visible, indicative of covalent binding, with the highest activity being observed for 20 (0.33 nM at 60 min preincubation time).
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Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.
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