Investigating the role of common cis-regulatory variants in modifying penetrance of putatively damaging, inherited variants in severe neurodevelopmental disorders.

Results from PrediXcan 30 (in blood) supported our hypothesis that parents would have higher predicted gene expression than their children when testing dominant and recessive DD genes containing putatively damaging PTVs, but this result was only nominally significant and did not pass multiple testing correction ( p < 0.05) (Supplementary Fig. 9 ).

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