Neoadjuvant chemotherapy is associated with suppression of the B cell-centered immune landscape in pancreatic ductal adenocarcinoma.

Analyzing the stromal compartment and thus excluding TLS-associated B cells, this effect was significant in the intratumoral region (p=0.047) and displayed a strong trend in the peritumoral region (p=0.058).

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In addition, proliferating lymphocytes displayed highly significant differences, as the median frequency of both CD3 + Ki67 + T cells as well as CD20 + Ki67 + B cells was over 10-fold lower in neoadjuvant-treated patients ( Figure 4A ).

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