TGF-β mRNA levels in circulating extracellular vesicles are associated with response to anti-PD1 treatment in metastatic melanoma.

The PFS and OS univariate models (estimated from 1000-boot-strapped replications of the data) showed a strong significant association with the expression of TGF-β ( p = 0.003 and p = 0.002) and a slightly significant association with LDH and NLR values ( p = 0.04) ( Supplementary Table S2 ).

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