Relating pre-treatment non-Gaussian intravoxel incoherent motion diffusion-weighted imaging to human papillomavirus status and response in oropharyngeal carcinoma.

Cluster one showed a significantly higher contribution in HPV-negative tumors compared to HPV-positive tumors (p = 0.033), while cluster three showed a trend towards lower contribution in HPV-negative tumors compared to HPV-positive tumors (p = 0.054) ( Fig. 3 c). 3.4 Tumor response, HPV status, and conventional DWI and NG-IVIM DWI parameters Due to the rare occurrence of PD in HPV-positive patients within one year (2 out of 18 patients), subgroup analysis was only performed for the HPV-negative patient group, in which 6 out 18 had PD within one year after treatment.

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