Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis.

Virulence · 2024 · PMC11028026 · PMID 38629410

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did not reach statistical significanceno p-value reported

Furthermore, the frequency of CD4dimCD8+ T cells in sHLH was indeed slightly higher than in DCs, but this difference did not reach statistical significance.

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a decreasing trendno p-value reported

In comparison to disease controls (DCs), naive B cells (CD27-IgD+) and memory B cells decreased (66.900 (48.020, 77.850) vs 78.600 (68.400, 87.100); 10.100 (4.600, 16.240) vs 13.200 (6.300, 18.200)), while plasma B cells and double negative B cells exhibited significant increases. The numbers of NK cells displayed a decreasing trend from HCs to DCs and sHLH groups.

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