Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity.

Hum Mol Genet · 2024 · PMC11031360 · PMID 38641551

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did not reach statistical significanceno p-value reported

Interestingly, transfection with pBABE-WT TERT / TERC showed a tendency to protect cells from late apoptosis although the data did not reach statistical significance.

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