Boolean gating confirmed an increasing trend of active (CD69 + CD107a + ) (Fig. 3e ) and proliferative (Ki67 + ) (Fig. 3f ) polyfunctional CD4 + and CD8 + T cells with cytolytic capabilities (GZMA + PRF1 + ) after stimulation.
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Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial.
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Patients with CR or PR showed a trend toward a greater magnitude of IFNγ response (Extended Data Fig. 7c ).