Integrating Electronic Health Records and Polygenic Risk to Identify Genetically Unrelated Comorbidities of Schizophrenia That May Be Modifiable.

Our EHR-based comorbidity profiles of schizophrenia showed highly significant consistency across 2 independent health care institutions, demonstrating the overall robustness of our comorbidity measure (Pearson’s r = 0.79, for all phecode pairs and r = 0.85 for schizophrenia specifically).

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We identified 15 phenotypes without a nominally significant PRS association including adverse drug events, as well as recurrent seizures, extrapyramidal disease and abnormal movement disorder, tachycardia, and torsion dystonia, which have all been previously linked to antipsychotic treatment ( 66 , 67 , 68 , 70 , 71 , 72 ), thus validating our hypothesis.

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