Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults.

A significant interaction for APOE ε4 carriage and time ( P = 0.001) and a trend toward significance for the three‐way interaction (moderate/severe sleep disturbance, P = 0.046, sleep duration category < 6 hours, P = 0.085, and sleep efficiency category 65%–85%, P = 0.070) confirmed modeling stratified for APOE ε4 carriage was warranted.

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3.5 Sleep disturbance score and rate of brain Aβ accumulation After Bonferroni correction for multiple comparisons, a nominally significant three‐way interaction was observed among moderate/severe sleep disturbance, APOE ε4 carriage, and time (β = 2.35 ± 1.17, P = 0.046), with respect to rate of brain Aβ accumulation.

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